This error results from unprocessed profile updates within the connector. You will want to process the appropriate profile update for the support within the connector, then retry processing the event registration or donation. 

Step 1: How to bulk process Profile Updates in the Raisers Edge Sphere Connector

Step 2: How to bulk process donation or event registration transactions in the Blackbaud Sphere Plug-In

If the error still persists on the transaction when attempting to process it within the Sphere Connector, chat with support and reference this article