Error: The request failed with an empty response

Sphere and RE users may receive the error "The request failed with an empty response" while trying to access Sphere through the connector.
We found that the host client has an internet appliance which locks down internet usage based on host IP address. This particular client has an extensive Citrix farm and block most servers access to the internet. 
Once the IT person realized this was an internet facing application they changed the policy from full lockdown to standard usage. The connector was then able to communicate via the internet and therefore have access to Sphere database.

Steps to Duplicate

Client is Hosted

1. Log into RE
2. Click on Sphere icon on the left
3. Click the Sphere link
Result: a pop-up error appears immediately.

Environment

 Blackbaud Sphere

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