The GIFTS Connections Server uses IIS as the connection between GIFTS Connection and your web browser. When IIS is installed on Windows Server 2003, the default security settings only allow it to serve static content (HTML). When GIFTS requests its dynamic content (Active Server Pages), an error is generated because IIS is not allowing the use of dynamic content.
To permit IIS to serve dynamic content, the administrator must unlock this content in the Web service extensions node in IIS Manager. Instructions for unlocking dynamic content in IIS are provided by Microsoft Knowledge Base article 315122: http://support.microsoft.com/default.aspx?scid=kb;en-us;315122