Error: Unable to access The Raiser's Edge 7. The Raiser's Edge 7 database signature appears to have been altered - when logging in

When logging into The Raiser's Edge, a user may receive the following message and be unable to log into the database:  Unable to access The Raiser's Edge 7. The Raiser's Edge 7 database signature appears to have been altered.
Contact Support and reference this article. 

Environment

 7.91.5056 patch 16

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