Calculate segment counts is automatically marked and grayed out when trying to Activate a Marketing Effort whose segments have already been calculated.

When attempting to Activate a Marketing Effort, the option 'Calculate segment counts' is marked and grayed out even though the Marketing Effort's segments have already been calculated. 
Download and install the latest patch, which contains all fixes from previous patches. If you are running an older version, download and install the latest version and then the patch. 

Work Around:

Use unique selections for each Marketing Effort.

Environment

 2.91.1535.54
 2.92.537, patch 50 ; 2.91.1535, patch 69

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