This depends on what changes you are making.

If you are upgrading Raisers Edge without moving the server or making changes to the Operating System, no changes to the Raisers Edge Connector should be necessary.

If you are moving the Raisers Edge server, upgrading the Operating System the server resides on, or changing the IP address of the server in anyway, then you will need to update the configuration of the Raisers Edge Connector.

For information on changing those configurations, please refer to the documentation here.